1197-18-8

  • Product Name:Tranexamic acid
  • Molecular Formula:C8H15NO2
  • Purity:99%
  • Molecular Weight:157.21
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Product Details

Purity:99%

We supply Cosmetics Grade Tranexamic acid 1197-18-8, In Stock.

1197-18-8 Name

Name

Tranexamic acid

Synonym

TIMTEC-BB SBB006715;TRANS-4-AMINOMETHYL-1-CYCLOHEXANECARBOXYLIC ACID;trans-4-aminomethylcyclohexane-1-carboxylate;TRANS-4-(AMINOMETHYL)CYCLOHEXANECARBOXYLIC ACID;cyclocapron;cyklokapron;dv-79;emorhalt

 

1197-18-8 Biological Activity

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Cardiovascular Disease

 

1197-18-8 Chemical & Physical Properties

Melting point 

>300 °C(lit.)

Boiling point

300.2±15.0 °C at 760 mmHg

Density

1.1±0.1 g/cm3

Molecular Formula

C8H15NO2

Molecular Weight

157.210

Flash Point

135.4±20.4 °C

PSA

63.32000

LogP

0.31

Exact Mass

157.110275

Vapour Pressure

0.0±1.3 mmHg at 25°C

Index of Refraction

1.497

storage temp. 

2-8°C

Water Solubility

1G/6ML

Cosmetics Grade Tranexamic acid 1197-18-8

Tranexamic acid (TXA) is an efficient antifibrinolytic agent which is a derivative of aminomethylbenzoic acid, and a kind of antifibrinolytic drugs to stop bleeding. The hemostasis mechanism of tranexamic acid is similar to aminocaproic acid and aminomethylbenzoic acid, but the effect is stronger. The strength is 7 to 10 times of aminocaproic acid, 2 times of aminomethylbenzoic acid, but toxicity is similar. The chemical structure of tranexamic acid is similar to lysine, competitive inhibition of plasmin original in fibrin adsorption, to prevent their activation, protection fiber protein not to degrade by plasmin and dissolve, eventually achieve hemostasis.Tranexamic acid is available in intravenous and oral formulations. It is safe and effective in both medical and surgical patients. In the presence of tranexamic acid, the lysine receptor binding sites of plasmin for fibrin are occupied, preventing binding to fibrin monomers, thus preserving and stabilizing fibrin’s matrix structure.

InChI:InChI=1/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-

1197-18-8 Relevant articles

In reply: Accidental infusion of tranexamic acid via a thoracic epidural catheter

CL Pysyk, L Filteau

Canadian Journal of Anesthesia/Journal canadien d'anesthésie (2023)

Patel for his interest in our case report of a patient with accidental administration of tranexamic acid (TXA) into the epidural space.

Tranexamic acid is not associated with decreased infection risk after primary shoulder arthroplasty: a cohort study of 9276 patients

Jacob Gorbaty MD , Priscilla H. Chan MS , Matthew D. McElvany MD , Heather A. Prentice PhD , Edward H. Yian MD

Journal of Shoulder and Elbow Surgery Volume 32, Issue 3, March 2023, Pages 581-588

The use of tranexamic acid (TXA) is associated with less blood loss and reduced transfusion risk after shoulder arthroplasty surgery. In a multicenter cohort of more than 9000 primary shoulder arthroplasty procedures, the use of preoperative TXA was not associated with a decrease in the 5-year probability of revision for deep infection.

1197-18-8 Process route

4-aminomethyl-cyclohexanecarboxylic acid
1197-17-7,1197-18-8,701-54-2

4-aminomethyl-cyclohexanecarboxylic acid

Conditions
Conditions Yield
 
 
 
 
 
 
C<sub>12</sub>H<sub>17</sub>NO<sub>5</sub>
953817-12-4

C12H17NO5

maleic anhydride
108-31-6

maleic anhydride

trans-4-aminomethyl-cyclohexyl-carboxylic acid
1197-18-8

trans-4-aminomethyl-cyclohexyl-carboxylic acid

Conditions
Conditions Yield
With hydrogenchloride; In water; for 1h; Kinetics;
 

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